アクセス数 : ?
ダウンロード数 : ?
ID 111498
著者
Okazaki, Michiyo Kochi Red Cross Hospital
Shimizu, Ichiro The University of Tokushima
Ishikawa, Momoko Tokushima Prefectural Miyoshi Hospital
Fujiwara, Soichiro Tokushima Prefectural Miyoshi Hospital
Yamamoto, Hirofumi Tokushima Prefectural Miyoshi Hospital
Shiraishi, Tatsuhiko Tokushima Prefectural Miyoshi Hospital
Horie, Takahiro Tokushima Prefectural Miyoshi Hospital
Iuchi, Arata Tokushima Prefectural Miyoshi Hospital
キーワード
rabeprazole
COX-2
PGE2
LTB4
H2 blocker
資料タイプ
学術雑誌論文
抄録
AIM : Prostaglandins (PGs) and leukotrienes (LTs) are major factors involved in the defense of the gastric mucosa against ulcer formation. However, little is still known about the gastromucosa-protecting action of proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2 blockers) in patients with gastric ulcer. We therefore examined the effectiveness of a PPI in protecting the gastric mucosa.
METHODS : We compared the PGE2 and LTB4 levels and the expression levels of cyclooxygenase (COX)-1 and COX-2 mRNA in the gastric mucosa in gastric ulcer patients between the group treated for 8 weeks with a PPI, rabeprazole (PPI group ; n=5), and the group treated for 8 weeks with an H2 blocker, ranitidine (H2 blocker group ; n=6), as well as in nonulcer subjects (control group ; n=5).
RESULTS : The mucosal levels of PGE2 and COX-2 mRNA expression were significantly lower in the ulcer patients than those in the nonulcer patients, whereas the LTB4 level was significantly higher in the ulcer patients than that in the nonulcer patients, and it was also significantly lower in the ulcerated mucosa than that in the nonulcerated mucosa. The PPI group had a significantly increased PGE2 and decreased LTB4 levels in comparison to the H2 blocker group during the ulcer-healing stage. The COX-1 mRNA expression showed no difference among the PPI and H2 blocker groups or between before and after the treatment. However, the COX-2 mRNA expression increased in the PPI group more than that in the H2 blocker group during the ulcer-healing stage.
CONCLUSION : These findings demonstrated the significant gastric-mucosa-protecting effect of PPI by increasing the PGE2 production and reducing the LTB4 production.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
54
1-2
開始ページ
83
終了ページ
90
並び順
83
発行日
2007-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系