| ID | 119641 |
| タイトル別表記 | Metabolic Phenotypes and Cancer Risk in the J-MICC
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| 著者 |
Nguyen, Tien Van
Thai Binh University of Medicine and Pharmacine
Unohara, Taichi
Tokushima University
Tanaka, Keitaro
Saga University
Shimanoe, Chisato
Saga University
Nagayoshi, Mako
Nagoya University
Tamura, Takashi
Gifu University
Kubo, Yoko
Nagoya University
Kato, Yasufumi
Nagoya University
Oze, Isao
Aichi Cancer Center Research Institute
Ito, Hidemi
Aichi Cancer Center Research Institute
Michihata, Nobuaki
Chiba Cancer Center
Nakamura, Yohko
Chiba Cancer Center Research Institute
Tanoue, Shiroh
Kagoshima University
Koriyama, Chihaya
Kagoshima University
Suzuki, Sadao
Nagoya City University
Nakagawa-Senda, Hiroko
Nagoya City University
Koyama, Teruhide
Kyoto Prefectural University of Medicine
Tomida, Satomi
Kyoto Prefectural University of Medicine
Kuriki, Kiyonori
University of Shizuoka
Takashima, Naoyuki
Kyoto Prefectural University of Medicine
Harada, Akiko
Shiga University of Medical Science
Wakai, Kenji
Nagoya University
Matsuo, Keitaro
Aichi Cancer Center Research Institute
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| キーワード | Cancer incidence
cohort study
metabolic syndrome
metabolically unhealthy obesity
Japanese
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| 資料タイプ |
学術雑誌論文
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| 抄録 | The present study investigated the relationship between metabolic phenotypes and the risk of cancer in a Japanese population using the criteria of metabolic phenotypes based on an examination and those based on questionnaires. We used data from 25,357 subjects for examination-based analyses and those from 53,042 subjects for questionnaire-based analyses in the Japan Multi-Institutional Collaborative Cohort Study. Metabolic phenotypes were defined by classifying subjects according to their BMI (obesity: BMI ≥25 kg/m2; normal weight: BMI <25 kg/m2) and the number of metabolic abnormalities. Metabolic abnormalities were defined according to metabolic syndrome components of the Joint Interim Statement Criteria for examination-based analyses and self-reported histories of diabetes, dyslipidemia, and hypertension for questionnaire-based analyses. Cox proportional hazards regression analyses adjusted for potential confounders were performed for total and site-specific cancer incidence according to metabolic phenotypes. Metabolically unhealthy obesity (MUHO) was significantly associated with cancer incidence in both examination-based [HR (95% CI): 1.17 (1.01-1.36)] and questionnaire-based analyses [HR (95% CI): 1.15 (1.04-1.26)]. Regarding site-specific cancer in questionnaire-based analyses, metabolically healthy obesity and MUHO were associated with colorectum and liver cancers in all subjects and with breast cancer in female subjects. Subjects with a metabolically unhealthy normal weight had a higher risk of pancreatic cancer. Moreover, MUHO was associated with corpus uteri cancer in female subjects. This prospective cohort study suggests that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults.
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| 掲載誌名 |
Cancer Research Communications
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| ISSN | 27679764
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| 出版者 | American Association for Cancer Research
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| 発行日 | 2024
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| 権利情報 | This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).
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| 言語 |
eng
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| 著者版フラグ |
著者版
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| 部局 |
医学系
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