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ID 112335
タイトル別表記
Choroidal Structure in Children with Anisohypermetropic Amblyopia
著者
Nishi, Tomo Nara Medical University
Ueda, Tetsuo Nara Medical University
Mizusawa, Yuutaro Nara Medical University
Sonoda, Shozo Kagoshima University
Uchino, Eisuke Kagoshima University
Sakamoto, Taiji Kagoshima University
Ogata, Nahoko Nara Medical University
資料タイプ
学術雑誌論文
抄録
Purpose
To compare the choroidal structure of the subfoveal area in the eyes of children with anisohypermetropic amblyopia to that of the fellow eyes and to age-matched controls using a binarization method of the images obtained by enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods
This study was performed at Nara Medical University Hospital, Tokushima University Hospital, and Kagoshima University Hospital, Japan. Forty amblyopic eyes with anisohypermetropic amblyopia and their fellow eyes (5.9 ± 2.1 years, mean ± standard deviation), and 103 age-matched controls (6.7 ± 2.4 years) were studied. The control eyes were divided into myopic, emmetropic, and hyperopic eyes. The total choroidal area, luminal area and stromal area of the subfoveal choroid were measured by the binarization method. The luminal/ stromal ratio and the axial length of the amblyopic eyes were compared to that of the control eyes.

Results
The total choroidal area in the amblyopic eyes was significantly larger than that of the fellow eyes (P = 0.005). The luminal/stromal ratio was significantly larger in the amblyopic eyes than that of the fellow eyes (P<0.001) and the control hyperopic eyes (P<0.001). There was a significant negative correlation between the luminal/stromal ratio and the axial length in the control eyes (r = -0.30, P = 0.001), but no significant correlation was found in the amblyopic eyes.

Conclusions
The choroidal structure of the amblyopic eyes was different from that of the fellow and the control hyperopic eyes. The choroidal changes are related to amblyopia.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
11
10
開始ページ
e0164672
発行日
2016-10-13
権利情報
Copyright: © 2016 Nishi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院