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ID 115646
タイトル別表記
日本の伝統的な漢方薬である大建中湯は推進性の運動パターンを誘導することにより結腸輸送を促進する
著者
久保田, 訓世 徳島大学大学院医科学教育部(医学専攻)
Mase, Akihito Tsumura & Co.
Matsushima, Hiroaki Tsumura & Co.
Fujitsuka, Naoki Tsumura & Co.
Yamamoto, Masahiro Tsumura & Co.
Taketomi, Akinobu Hokkaido University
Kono, Toru Tokushima University|Hokkaido University|Sapporo Higashi Tokushukai Hospital
キーワード
Colon
daikenchuto
hydroxy‐α‐sanshool
peristaltic contraction
postoperative ileus
資料タイプ
学位論文
抄録
Background: The traditional Japanese herbal medicine, daikenchuto (DKT), has been used to treat constipation and postoperative ileus. However, the precise mechanisms involved in the pharmacological effects of DKT remain uncertain. The aim of this study was to clarify the effect of DKT on motor patterns and transit activity in the isolated rat colon.
Methods: The entire colon or segments of the proximal colon in rats were isolated and placed in Krebs solution. The motility of the colon was evaluated by analyzing spatiotemporal maps of diameter derived from video imaging and measuring the intraluminal pressure in the anal end of the proximal colon, and the transit time of a plastic bead through the entire isolated colon.
Key Results: Several types of propagating contractions were observed in the isolated entire colon. When DKT was added to Krebs solution, the frequency of large‐extent anal propagating contractions increased. DKT treatment increased the intraluminal pressure in the isolated proximal colon, which was related to the propagating contractions. This effect was abolished by treatment with the neural blocker tetrodotoxin. These findings suggest DKT induced peristaltic contractions in the isolated colon. DKT accelerated colonic transit activity, which was related to peristaltic contractions induction in the colon. These effects were also observed in the colons treated with bethanechol and the active ingredient of DKT, hydroxy‐α‐sanshool.
Conclusions and Inferences: Daikenchuto could enhance colonic transit activity by inducing peristaltic contractions, which may be mediated by the activation of the enteric nervous system in the colon.
掲載誌名
Neurogastroenterology & Motility
ISSN
13652982
cat書誌ID
AA11017929
出版者
John Wiley & Sons
31
11
開始ページ
e13689
発行日
2019-08-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Kunitsugu Kubotaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3504号
学位記番号
甲医第1493号
学位授与年月日
2021-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系