ID | 117253 |
著者 |
Hutami, Islamy Rahma
Tokushima University|Sultan Agung Islamic University
Khurel‐Ochir, Tsendsuren
Tokushima University
坂巻, 拓馬
Tokushima University
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キーワード | HIF1
M1/M2 macrophage
S1P
wound healing
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資料タイプ |
学術雑誌論文
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抄録 | Accumulating evidence indicates that the molecular pathways mediating wound healing induce cell migration and localization of cytokines to sites of injury. Macrophages are immune cells that sense and actively respond to disturbances in tissue homeostasis by initiating, and subsequently resolving, inflammation. Hypoxic conditions generated at a wound site also strongly recruit macrophages and affect their function. Hypoxia inducible factor (HIF)-1α is a transcription factor that contributes to both glycolysis and the induction of inflammatory genes, while also being critical for macrophage activation. For the latter, HIF-1α regulates sphingosine 1-phosphate (S1P) to affect the migration, activation, differentiation, and polarization of macrophages. Recently, S1P and HIF-1α have received much attention, and various studies have been performed to investigate their roles in initiating and resolving inflammation via macrophages. It is hypothesized that the HIF-1α/S1P/S1P receptor axis is an important determinant of macrophage function under inflammatory conditions and during disease pathogenesis. Therefore, in this review, biological regulation of monocytes/macrophages in response to circulating HIF-1α is summarized, including signaling by S1P/S1P receptors, which have essential roles in wound healing.
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掲載誌名 |
International Journal of Molecular Sciences
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ISSN | 14220067
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出版者 | MDPI
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巻 | 22
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号 | 16
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開始ページ | 8992
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発行日 | 2021-08-20
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権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
歯学系
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