アクセス数 : ?
ダウンロード数 : ?
ID 113595
著者
Siriwardena, B S M S Hiroshima University|University of Peradeniya
Ogawa, I Hiroshima University
Udagama, M N G P K University of Peradeniya
Tilakaratne, W M University of Peradeniya
高田, 隆 Hiroshima University
資料タイプ
学術雑誌論文
抄録
Background: Nodal metastasis is a major prognostic indicator for oral squamous cell carcinoma (OSCC) progression. Recently, it has been revealed that lymphangiogenic growth factor VEGF-C and its receptor Flt-4 play an important role for invasion and metastasis in cancer cells.
Aim: To examine VEGF-C expression and its correlation with lymphatic status, including the number of lymph vessels and lymphatic invasion, tumour invasion and metastasis in OSCC.
Methods: Intratumoural and peritumoural lymphatic vessels were examined using D2-40 in 54 OSCC cases and correlated with VEGF-C expression and clinicopathological findings. The histological pattern of invasion and pathological findings were compared.
Results: High expression of VEGF-C was frequently observed in OSCC and was associated with increased number of lymph vessels and lymphatic invasion. VEGF-C was well correlated with invasion pattern and metastasis.
Conclusions: Results suggest that VEGF-C may play an important role for lymphangiogenesis and invasion in the metastatic process and can be a strong predicting factor for metastasis of OSCC.
掲載誌名
Journal of Clinical Pathology
ISSN
14724146
00219746
cat書誌ID
AA00695564
出版者
British Medical Association|The Association of Clinical Pathologists
61
1
開始ページ
103
終了ページ
108
発行日
2007-03-09
権利情報
This article has been accepted for publication in Journal of Clinical Pathology, 2007 following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/jcp.2007.047662.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系