ID 110727
著者
マツヤマ, カズオ Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
フクダ, ヨウ Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
ミヤケ, ヒデノリ Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
ヨギタ, シロウ Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
田代, 征記 Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
キーワード
portacaval shunt
hepatic functional reserve
hepatic venous blood sampling
MEGX
ICG
資料タイプ
学術雑誌論文
抄録
Background. Hepatocellular carcinoma is likely to accompany liver cirrhosis in which the portal pressure increases with portasystemic shunt. When portal tumor thrombus is present in the primary bifurcation, blood flow differs between the thrombolic lobe and the non-thrombolic lobe. In those cases, it is difficult to evaluate exactly residual liver function by conventional test. Therefore, the following studies were performed. Materials and Methods. Adult mongrel dogs are divided into a control group(Cgroup), group undergoing ligation of the left portal branch(PL group), group undergoing portacaval anastomosis (PCS group) and group undergoing both ligation of the left portal branch and portacaval anastomosis (PL+PCSgroup)(n=5). ICG-R15 andMEGX15 in peripheral venous blood and right hepatic venous blood were determined. Mitchondrial metabolic capacity (adenosine triphosphate level, energy charge)was measured by high-performance liquid chromatography using liver biopsied specimens. Results. The MEGX ratio (right hepatic venous blood MEGX15/peripheral venous blood MEGX 15) positively correlated with energy charge in the right hepatic lobe. Conclusions. In evaluating liver function of the right hepatic lobe during portacaval shunt and the left portal branch ligation, the MEGX ratio may sensitively reflect the mitochondrial function.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
51
1-2
開始ページ
84
終了ページ
95
並び順
84
発行日
2004-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系