ヒト免疫不全ウイルスHIVの分子遺伝学

Various mutants of human immunodeficiency virus. types 1 and 2 (HIV-1 and HIV-2) have been generated to do systemic genetic studies on virus replication, virus pathogenesis, AIDS animal models, and finally on the anti-AIDS therapy. We are particularly interested in the functions of the Gag proteins, the major viral proteins, and the accessory proteins (Vif, Vpx, Vpr, Vpu, and Nef) which are unique to HIV/SIV (simian immunodeficiey virus). In this brief review, we summarize our HIV projects with special reference to the functions of Gag and accessory proteins.