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ID 118348
タイトル別表記
Polymethoxyflavonids and T helper 17 cells
著者
Hirabayashi, Yuwa Tokushima University
Anzaki, Chieri Tokushima University
首藤, 恵泉 Okayama Prefectural University KAKEN研究者をさがす
Nii, Yoshitaka Tokushima Prefectural Industrial Technology Center
キーワード
polymethoxyflavonoids
nobiletin
sudachitin
T helper 17 cell
IL-17A
資料タイプ
学術雑誌論文
抄録
We examined the effects of polymethoxyflavonoids (PMFs) on T helper (Th) 17 cell differentiation in vitro and in vivo. Five different PMFs including nobiletin (NOB), sudachitin (SUD), demethoxysudachitin, heptamethoxyflavone and natsudaidain were used for the in vitro study, and effects of those flavonoids on Th17 responses were investigated. NOB and heptamethoxyflavone significantly suppressed the proliferation response, but SUD, demethoxysudachitin and natsudaidain did not suppress the proliferation response. All of the five flavonoids decreased IL-17A production. Mice with experimentally induced autoimmune encephalomyelitis were used as an in vivo Th17 differentiation model. We focused on two flavonoids, NOB and SUD, and examined the effects of those flavonoids. NOB significantly suppressed Th17 cell proliferation and cytokine responses, but SUD only decreased proliferation responses. The results suggest that the suppressive effect of NOB on Th17 response in vivo is stronger than that of SUD.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
70
1-2
開始ページ
166
終了ページ
170
並び順
166
発行日
2023-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系