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ID 114524
著者
Nagao, Mizuho Mie National Hospital
Borres, Magnus P. Thermo Fisher Scientific|Uppsala University
Petersson, Carl Johan Thermo Fisher Scientific
Nakayama, Satoshi Thermo Fisher Scientific
Kuwabara, Yu Mie National Hospital
Masuda, Sawako Mie National Hospital
Dykiel, Patrik Thermo Fisher Scientific
Fujisawa, Takao Mie National Hospital
キーワード
Asthma
Allergy
Children
Molecular allergy diagnostics
Pet allergen components
Component resolved diagnosis
Food allergy
Secretoglobin
Lipocalin
Sensitization
資料タイプ
学術雑誌論文
抄録
Background: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.
Methods: Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals’ outcome on asthma inception.
Results: At 2 years of follow-up, physician-diagnosed asthma was 19.7% (n = 49) and asthma diagnosed any time was 24% (n = 67). History of persistent cough and asthma of father, combination of milk- and wheat-allergy symptoms and dual sensitization to house dust mite and Japanese cedar were independent risk factors for asthma. Sensitization to dog was the most prevalent inhalant allergen at entry. Asthma children had a higher proportion of sensitization to dog, cat and horse allergens at entry compared with non-asthma children. Being sensitized to both food, house dust mite and pet allergens was strongly associated with asthma (p = 0.0006). Component resolved diagnosis for dog and cat allergens showed that IgE antibodies to Can f 1 and Fel d 1 was common even at very young age.
Conclusions: Early sensitization to inhalant allergens increases the risk of developing asthma as well as having milk and wheat allergy symptoms. Sensitization to dog, was common at an early age despite dog ownership. Sensitization to secretoglobin and lipocalins and less to serum albumins explained the pet sensitization.
掲載誌名
Clinical and Molecular Allergy
ISSN
14767961
出版者
Springer Nature|BioMed Central
15
開始ページ
4
発行日
2017-03-03
権利情報
© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
EDB ID
出版社版DOI
出版社版URL
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言語
eng
著者版フラグ
出版社版
部局
医学系