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ID 115675
タイトル別表記
尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。
Urinary adiponectin in DKD
著者
石津, 将 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
Ohishi, Mami Tokushima University
Akehi, Yuko Tokushima University
Aiba, Motohiro Tokushima Bunri University
Kawano, Tomoharu Tokushima Bunri University
橋田, 誠一 Ehime University
キーワード
diabetes kidney disease
urinary adiponectin
estimated glomerular filtration rate
資料タイプ
学位論文
抄録
Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease.
Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR).
Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR.
Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes.
掲載誌名
Journal of Diabetes and its Complications
ISSN
10568727
cat書誌ID
AA10843748
AA11531864
出版者
Elsevier
35
4
開始ページ
107848
発行日
2021-01-07
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Masashi Ishizuの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3503号
学位記番号
甲医第1489号
学位授与年月日
2021-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
先端酵素学研究所