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ID 74523
タイトル別表記
ジェネティック制御下にある発育鶏卵を用いた工学的in vivo 薬剤評価系の開発
著者
安部, 千秋 Graduate School of Advanced Technology and Science, The University of Tokushima
宇都, 義浩 Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
中田, 栄司 Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
堀, 均 Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Antioxidant
Artepillin C
Chick embryo chorioallantoic membrane
vascular injury
資料タイプ
紀要論文
抄録
The drug discovery research of clinical-use antioxidants, which may control various vascular
disorders caused by the oxidative stress, is extremely important. We present the development of an
in vivo evaluation system of antioxidants for their vascular protective activities using the chick
embryonic chorioallantoic membrane (CAM). In the case of 12-days chick embryos, the topical
administration of 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) induced their
vascular injuries against the CAM veins and venous capillaries but without substantial fatal damage.
Artepillin C, a potent natural antioxidant, did not show the chick embryo’s venous injury, and
pre-treatment with artepillin C would tend to protect the CAM veins injuries induced by the
post-administration of AAPH. These results suggest that artepillin C might be able to protect the
AAPH-induced vascular injury in in vivo. In conclusion, we showed the possibility of in vivo
evaluation system of antioxidants for their vascular protective activities using the chick embryo.
掲載誌名
徳島大学大学院ソシオテクノサイエンス研究部研究報告
ISSN
21859094
cat書誌ID
AA12214889
54
開始ページ
70
終了ページ
74
並び順
70
発行日
2009
フルテキストファイル
言語
eng
部局
生物資源系