ID | 111587 |
著者 |
Sakakibara, Hiroyuki
The University of Tokushima
Ishida, Kaori
The University of Tokushima
井澤, 有紀
The University of Tokushima
Minami, Yuko
The University of Tokushima
Saito, Satomi
The University of Tokushima
Butterweck, Veronika
University of Florida
|
キーワード | depression
forced swimming test
brain function
serotonergic ratio
ERK1/2
|
資料タイプ |
学術雑誌論文
|
抄録 | Chronic stress has been reported to be an essential factor for depression. In this study, the effect of forced swimming stress on neurotransmitters and cellular signaling pathway contributing to brain functions was investigated using the forced swimming test (FST) in order to understanding of mechanisms to regulate stress signals in brain. Antidepressant drug, imipramine, significantly reduced the immobility time of male rats in the FST by 85% at a dose of 15mg/kg for 2 weeks. This result indicated that the swimming stress caused a depressed state in the rats without administration of imipramine. Swimming stress significantly lowered the serotonergic ratio and also markedly enhanced the phosphorylation of ERK1/2 in the hypothalamus region compared to the rats without FST. These phenomena maybe included in key mechanisms of the development of depression.
|
掲載誌名 |
The Journal of Medical Investigation
|
ISSN | 13496867
13431420
|
cat書誌ID | AA11166929
AA12022913
|
出版者 | Faculty of Medicine Tokushima University
|
巻 | 52
|
号 | Supplement
|
開始ページ | 300
|
終了ページ | 301
|
並び順 | 300
|
発行日 | 2005-11
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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