ID | 111274 |
タイトル別表記 | 進行頭頸部癌に対して化学放射線療法中の患者において経皮内視鏡的胃瘻造設術が治療中断や栄養状態に及ぼす効果
Efficacy of PEG on head and neck cancer
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著者 |
陣内, 自治
University of Tokushima
高岡, 司
University of Tokushima
古北, 由仁
University of Tokushima
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キーワード | percutaneous endoscopic gastrostomy
PEG
nutritional support
chemoradiotherapy
head and neck cancer
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資料タイプ |
学位論文
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抄録 | Objective : Efficacy of percutaneous endoscopic gastrostomy (PEG) on unplanned treatment interruption and nutritional status was examined in patients undergoing chemoradiotherapy (CRT) for advanced head and neck cancer. Methods :We retrospectively reviewed hospital charts of 44 patients with advanced head and neck cancer who were treated with CRT. Results : CRT-induced mucositis of grade 3 or worse and inadequate oral intake of less than one third of their usual intake developed in 33 patients who were recommended PEG placement, but not in 11 patients. Thirteen patients accepted PEG placement and then completed CRT (compliant group). However, among 20 patients who refused both PEG and nasogastoric tube (NGT) placements (non-compliant group), 10 required unplanned interruptions of CRT at a radiation dose around 30-40 Gy (UI-CRT group) while 10 others could complete CRT without interruption (C-CRT group) CRT. Total serum protein levels were significantly decreased after CRT in all patients. Discussion : It is suggested that therapeutic PEG placement is useful for preventing unplanned interruption of CRT in patients with advanced head and neck cancer. After severe mucositis and inadequate oral intake have developed during CRT, PEG placement should be considered before the radiation therapy dose of 30 Gy.
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掲載誌名 |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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cat書誌ID | AA11166929
AA12022913
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出版者 | Faculty of Medicine Tokushima University
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巻 | 62
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号 | 3-4
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開始ページ | 173
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終了ページ | 176
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並び順 | 173
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発行日 | 2015-08
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備考 | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201508041003.pdf 論文本文 : LID201510261013.pdf 本論文は,著者Masakazu Godaの学位論文として提出され,学位審査・授与の対象となっている。 著者表記誤記あり(誤)Koich Tamura→(正) Koichi Tamura |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第2864号
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学位記番号 | 甲医第1253号
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学位授与年月日 | 2015-07-23
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
医学系
病院
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