Improved Glucose Variability by Low Carbohydrate Diet in Female Diabetic Patients

Background: Discussion of Low Carbohydrate Diet (LCD) and Calorie Restriction (CR) has been observed. Authors have continued clinical research on LCD, CR and Morbus (M) value for years.
Subjects and Methods: Subjects were 81 female patients with type 2 diabetes mellitus (T2DM). Methods included i) basal tests on diabetes, ii) daily profile of blood glucose, average glucose, M value for CR meal, iii) same exam of ii) for 2 days of LCD, iv) Triglyceride check for 12 days of LCD, v) analyses of these biomarkers.
Results: Obtained data were as follows: average age 62.4 years old, median values are HbA1c 7.2%, fasting glucose 147 mg/dL, IRI 6.8 μU/mL, HOMA-R 2.5, HOMA-β 28.7, respectively. Median values on day 2 vs 14: average glucose 173 vs 130 mg/dL, M value 62.4 vs 9.6, respectively. There was significant correlations between M value and HbA1c (p<0.01), and between average glucose and HbA1c (p<0.01). Triglyceride value was decreased for 12 days of LCD from 103 to 79 mg/dL.
Discussion and Conclusion: The results suggested that LCD showed positive effects for improving glucose variability and lipid metabolism. Furthermore, these findings would become fundamental and reference data for the future research development in this field.

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