直近一年間の累計
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ID 119107
著者
Yasui, Saya Anan Medical Center
Kaneko, Yousuke Anan Medical Center
山上, 紘規 Anan Medical Center|Tokushima University 徳島大学 教育研究者総覧
Hosoki, Minae Anan Medical Center
Hori, Taiki Anan Medical Center|Tokushima University
Tani, Akihiro Anan Medical Center
乙田, 敏城 Tokushima University
キーワード
dehydroepiandrosterone sulfate
presarcopenia
sarcopenia
dynapenia
type 2 diabetes
資料タイプ
学術雑誌論文
抄録
Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. Although skeletal muscle disorders are often found in diabetic people, the clinical significance of DHEAS in skeletal muscle remains unclear. Therefore, we aimed to determine whether DHEAS is associated with the development of skeletal muscle disorders in individuals with type 2 diabetes (T2D). A cross-sectional study was conducted in 361 individuals with T2D. Serum DHEAS levels, skeletal muscle mass index (SMI), handgrip strength (HS), and gait speed (GS) were measured in the participants. Pre-sarcopenia, sarcopenia, and dynapenia were defined according to the definitions of the AWGS 2019 criteria. DHEAS level was positively associated with HS but not with SMI or GS after adjustment of confounding factors. Multiple logistic regression analyses in total subjects showed that DHEAS level had an inverse association with the prevalence of dynapenia but not with the prevalence of pre-sarcopenia or sarcopenia. Furthermore, a significant association between DHEAS level and dynapenia was found in males but not in females. ROC curve analysis indicated that cutoff values of serum DHEAS for risk of dynapenia in males was 92.0 μg/dL. Therefore, in male individuals with T2D who have low serum levels of DHEAS, adequate exercise might be needed to prevent dynapenia.
掲載誌名
Metabolites
ISSN
22181989
出版者
MDPI
13
11
開始ページ
1129
発行日
2023-11-03
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系
先端酵素学研究所