ID | 113365 |
タイトル別表記 | Senescence-accelerated mouse-prone 8 (SAMP8)マウスにおけるオリーブオイル摂取の老化への効果
Effects of olive oil in SAMP8 mice
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著者 |
板東, 正浩
徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
升本, 早枝子
Tokushima University
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キーワード | Mediterranean diet
olive oil
MUFA
SAMP8
aging
passive avoidance
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資料タイプ |
学位論文
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抄録 | Background : Mediterranean diets have been linked to a reduced risk of cancer, vascular illnesses, Parkinson’s and Alzheimer’s disease. Olive oil is the primary fat source in the Mediterranean diet ; however, only a few studies have investigated the effect of olive oil on aging. In the present study, we aimed to determine whether consumption of olive oil significantly influences aging and memory in senescence-accelerated mouse-prone 8 (SAMP8). Methods : SAMP8 and senescence-accelerated mouse resistant 1 (SAMR1) mice were fed either 7% soy oil or 1% olive oil and 6% soy oil during a six-month study period. Reduction in memory in passive avoidance learning was examined after two months from the initiation of the experiment. Results : The weight of organs including the liver, kidney, spleen, and fat tissue changed significantly and memory performance was reduced in SAMP8 than in SAMR1 mice. There were no significant differences in SAMP8 and SAMR1 mice; however, blood triglyceride level decreased significantly in SAMP8 mice fed on olive oil. Conclusions : These results suggest that consuming olive oil may not have a protective role in aging and memory recall, but beneficial effects may be related to improvement in lipid metabolism.
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掲載誌名 |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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cat書誌ID | AA12022913
AA11166929
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出版者 | Tokushima University Faculty of Medicine
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巻 | 66
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号 | 3-4
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開始ページ | 241
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終了ページ | 247
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並び順 | 241
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発行日 | 2019-08
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Masahiro Bandoの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3276号
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学位記番号 | 甲栄第265号
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学位授与年月日 | 2019-03-22
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学位名 |
博士(栄養学)
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学位授与機関 |
徳島大学
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部局 |
医学系
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