Desensitization treatment with cisplatin after carboplatin hypersensitivity reaction in gynecologic cancer

Platinum-based chemotherapy is the standard regimen for the treatment of gynecologic
cancers ; however, hypersensitivity reactions (HR) to platinum often lead to discontinuation
of this effective treatment. Here we performed a desensitization protocol
for platinum infusion in 3 patients who required platinum re-administration after developing
HR. Two patients (Case 1 and 2) were treated with the desensitization protocol
successfully without developing HR during the subsequent 3 courses. Case 3 tolerated
desensitization well for 2 courses, but in the 3rd course, she developed severe HR immediately
after the initiation of cisplatin infusion because the desensitization protocol was
unintentionally omitted. These cases show the usefulness and effectiveness of the desensitization
protocol for the continuation of platinum treatment in patients who have undergone
an extended number of treatments.

The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html