ID | 116889 |
タイトル別表記 | 雌ラットにおいて生殖腺の状態とエストロゲン環境が視床下部オキシトシン遺伝子発現および血清オキシトシンレベルに及ぼす影響
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著者 |
德井, 貴子
徳島大学大学院医科学教育部(医学専攻)
Yanagihara, Rie
Tokushima University
鎌田, 周平
Tokushima University
Takeda, Asuka
Tokushima University
今泉, 絢貴
Tokushima University
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キーワード | Oxytocin
Oxytocin receptor
Hypothalamus
Estradiol
Ovariectomy
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資料タイプ |
学位論文
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抄録 | Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. In this study, we showed that ovariectomy decreased rats' hypothalamic OT/OTR mRNA and serum OT levels, but did not affect their visceral fat OTR mRNA levels. The chronic administration of estradiol (E2) abrogated these ovariectomy-induced changes; i.e., it increased the rats' hypothalamic OT/OTR mRNA and serum OT levels, and may be associated with reductions in food intake and body weight gain. In addition, acute E2 administration increased the rats' hypothalamic OTR mRNA and serum OT levels, but did not affect their hypothalamic OT mRNA levels. Taken together, these results suggest that endogenous OT and/or OTR expression might be positively regulated by E2 and that the suppressive effects of E2 on appetite and body weight gain might be mediated, at least in part, by the OT system. Thus, we consider that OT might be a target hormone to pursue subsequent interventions of menopause for menopause-induced metabolic disorders.
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掲載誌名 |
Hormones and Behavior
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ISSN | 0018506X
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cat書誌ID | AA00665370
AA11539414
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出版者 | Elsevier
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巻 | 133
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開始ページ | 105005
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発行日 | 2021-06-08
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Takako Tokuiの学位論文として提出され,学位審査・授与の対象となっている。 |
権利情報 | © 2021 Elsevier Inc.
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3592号
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学位記番号 | 甲医第1521号
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学位授与年月日 | 2022-03-23
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
病院
医学系
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