ID | 110880 |
著者 |
ナガオ, タミコ
Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
ハッチョウ, カズキ
Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
ドイ, ナオヤ
Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
徳島大学 教育研究者総覧
フジワラ, サチ
Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
足立, 昭夫
Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
徳島大学 教育研究者総覧
KAKEN研究者をさがす
野間口, 雅子
Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
徳島大学 教育研究者総覧
KAKEN研究者をさがす
|
キーワード | HIV-1
Gag
CA
CypA,
TRIM5α
|
資料タイプ |
学術雑誌論文
|
抄録 | We previously generated a prototype monkey-tropic human immunodeficiency virus type 1 (HIV-1) designated NL-DT5R. This viral clone has a small region of simian immunodeficiency virus (SIV) within Gag capsid (CA) protein and also SIV Vif protein, but displays a poor growth phenotype in simian cells. To improve the growth potential of NL-DT5R, we have constructed a series of its gag variant viruses. Out of fourteen viral clones generated, five were infectious for simian HSC-F cells, and two of the infectious variants grew similarly with NL-DT5R. Taking their genome structures into consideration, our data here clearly show that a narrow CA region within the Gag protein, i.e., the domain around cyclophilin A (CypA)-binding loop, is critical for the growth ability of HIV-1 in simian cells.
|
掲載誌名 |
The journal of medical investigation : JMI
|
ISSN | 13431420
|
cat書誌ID | AA11166929
|
巻 | 56
|
号 | 1-2
|
開始ページ | 21
|
終了ページ | 25
|
並び順 | 21
|
発行日 | 2009-02
|
EDB ID | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
出版社版
|
部局 |
医学系
|