肺癌患者血清中における癌抑制遺伝子産物pRB に対する抗体の検出

Recently, serum antibodies against the oncogene and tumor suppressor gene products have been studied in patients with various types of cancer. Antibody against p53 tumor suppressor gene product among these antibodies was suggested to be useful for early diagnosis and evaluation of prognosis of patients with some types of cancer. In this article,we review clinical significance of antibodies against product of retinoblastoma gene (pRB),one of representative tumor suppressor genes. We also describe methods of detection of antibodies in sera from patients with lung cancer by immunoblotting assays using glutathione-S-transferase (GST)-RB fusion proteins.