ID | 114688 |
タイトル別表記 | Successful cord blood cell transplantation in a patient with refractory hepatosplenic T-cell lymphoma
臍帯血移植が奏効した肝脾型T細胞リンパ腫
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著者 |
高橋, 真美子
徳島大学
井上, 雄介
徳島大学
池亀, 彰茂
徳島大学
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キーワード | Hepatosplenic T-cell lymphoma
refractory
cord blood transplantation
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資料タイプ |
学術雑誌論文
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抄録 | Cord blood for transplant is collected from the umbilical cord and donated cord blood is tested, frozen and stored for future use. Cord blood stem cell transplantation(CBT)do not have to be as closely matched as bone marrow or peripheral blood stem cell transplantations, therefore we are able to perform CBT for refractory patients at optimal timing. Here, we report a 33 years old woman with refractory hepatosplenic T-cell lymphoma(HSTL)who achieved complete response ; CR after unrelated CBT. She complained of fever and abdominal pain, she was diagnosed with HSTL. She was refractory to several chemotherapy regimens, we planned to allogenic transplantation for her. However, she had no HLA-matched sibling donors and we were not able to find favorable unrelated donors from Japan Marrow Donor Program. Therefore, we decided to perform CBT for her. We used fludarabine(180mg/m2), busulfan(12.8mg/kg)and melphalan(80mg/m2) as conditioning regimens and we chose tacrolimus and MMF for graft versus host disease(GVHD) prophylaxis. On day 22 after transplantation, her neutrophil count engrafted, she suffered from acute GVHD(skin, gastrointestinal tract, grade2), she was improved by medical treatment. She achieved CR her disease status maintained over two years after CBT. HSTL is often refractory to chemotherapy, the clinical efficacy of hematopoietic stem cell transplantation may be expected. Our case suggests that CBT may be effective and feasible option for refractory HSTL who has no favorable HLA-matched donors.
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掲載誌名 |
四国医学雑誌
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ISSN | 00373699
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cat書誌ID | AN00102041
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出版者 | 徳島医学会
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巻 | 75
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号 | 5-6
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開始ページ | 221
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終了ページ | 226
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並び順 | 221
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発行日 | 2019-12-25
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フルテキストファイル | |
言語 |
jpn
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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