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ID 118205
タイトル別表記
膵内副脾発生類表皮嚢胞の発生機序・組織学的特徴に関する検討
Histological analysis of ECIPAS
著者
住田, 智志 徳島大学大学院医学研究科(医学専攻)
Miyakami, Yuko Tokushima University
柿本, 拓海 Tokushima University
小林, 智子 Tokushima University
Taira, Shu Fukushima University
キーワード
Epidermoid cyst in intrapancreatic accessory spleen
imaging mass spectrometry
lipid excretion
Pbx1
Tlx1
資料タイプ
学位論文
抄録
Background : Epidermoid cysts in intrapancreatic accessory spleen (ECIPAS) are a rare lesion. Its pathogenesis, including the origin of cystic epithelium, is not well established. We aimed to elucidate new aspects of the pathological features of ECIPAS to clarify its pathogenesis. Methods : Six cases of ECIPAS were included in this study. As well as histopathological analysis, to elucidate the features and nature of cystic epithelial cells, immunohistochemical analysis including Pbx1 and Tlx1 and imaging mass spectrometry was performed. Results : Histologically, the cysts were covered by either monolayered or multilayered epithelium. Immunohistochemistry revealed that the epithelial cells in multilayered epithelium exhibited different attributes between the basal and superficial layers. Few epithelial cells had abundant clear cytoplasm and were immunohistochemically positive for adipophilin, suggesting lipid-excreting function. The intracystic fluid contained cholesterol clefts and foamy macrophages, and imaging mass spectrometry revealed the accumulation of lipids. Immunohistochemical analysis indicated that the epithelial cells were positive for Pbx1 in some cases. Conclusion : Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
70
1-2
開始ページ
251
終了ページ
259
並び順
251
発行日
2023-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Satoshi Sumidaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3702号
学位記番号
甲医第1572号
学位授与年月日
2023-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院