ID | 115181 |
著者 |
Miyazaki, Aiko
Tokushima University
Kakiuchi, Naoya
Tokushima University
Okamoto, Kazumasa
Tokushima University
|
キーワード | Flow titration
flow ratiometry
high-throughput titration
nonaqueous titration
Japanese Pharmacopoeia drug
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資料タイプ |
学術雑誌論文
|
抄録 | Throughput rate of flow ratiometric titration has further been enhanced by shortening the lag time from the confluence of solutions upstream to the sensing of signal downstream and by optimizing analytical parameters. Feedback-based upward and downward scans of titrand/titrant flow ratio were repeated in order to offset the effect of the lag time and thus to locate the equivalence point. Subsequent faster fixed triangular wave-controlled scans in narrower range further increased the throughput rate. Analytical parameters such as scan rate and scan range were optimized. Maximally, 46.9 titrations/min was realized with reasonable precision (RSD = 1.79%). Applicability of the method to the quantitation of the Japanese Pharmacopoeia drugs (furosemide, isoniazid and prochlorperazine maleate) was verified, where the latter two drugs were determined by nonaqueous titrations.
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掲載誌名 |
Journal of Flow Injection Analysis
|
ISSN | 0911775X
24337374
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cat書誌ID | AA10962565
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出版者 | Japanese Association for Flow Injection Analysis
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巻 | 36
|
号 | 2
|
開始ページ | 97
|
終了ページ | 100
|
発行日 | 2019
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
薬学系
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