A recyclable hydrophobic anchor-tagged asymmetric amino thiourea catalyst

A novel recyclable thiourea-based, asymmetric organocatalyst containing a hydrophobic anchor has been developed. The chemical nature of the hydrophobic anchor contributes to the desirable characteristics of the recyclable catalyst. The hydrophobic anchor-tagged thiourea catalyst is highly soluble in less polar solvents compatible to the amino thiourea catalyst-mediated asymmetric reactions, but sparingly soluble in polar solvents used for recycle process. This asymmetric catalyst delivers a catalytic performance comparable to that of a parent catalyst and can be readily recycled from reactions.

This is the peer reviewed version of the following article: T. Jichu, T. Inokuma, K. Aihara, T. Kohiki, K. Nishida, A. Shigenaga, K.-i. Yamada, A. Otaka, ChemCatChem 2018, 10, 3402., which has been published in final form at https://doi.org/10.1002/cctc.201800714. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions