| ID | 111884 |
| 著者 |
Aihara, Keisuke
Tokushima University
Komiya, Chiaki
Tokushima University
|
| キーワード | Lactam-bridged peptide
Cyclic peptide
Ring-closing metathesis
Fmoc solid-phase peptide synthesis
Diimide reduction
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | A new approach has been developed for the synthesis of lactam-bridged cyclic peptides. Following the introduction of N-allyl glutamine and α-allylglycine into the peptide backbone, the side chains of these residues were subjected to a cyclization reaction by ring-closing metathesis (RCM). Reduction of the resulting peptide bearing olefin moiety was achieved using diimide, which was generated in situ from o-nitrobenzenesulfonyl hydrazine and piperidine, gave the corresponding saturated cyclic peptides.
|
| 掲載誌名 |
Tetrahedron
|
| ISSN | 00404020
|
| cat書誌ID | AA00861787
AA11539786
|
| 出版者 | Elsevier
|
| 巻 | 71
|
| 号 | 24
|
| 開始ページ | 4183
|
| 終了ページ | 4191
|
| 発行日 | 2015-05-01
|
| 権利情報 | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
|
| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
著者版
|
| 部局 |
薬学系
|
