Synthesis of a Stimulus-responsive Processing Device and Its Application to a Nucleocytoplasmic Shuttle Peptide

Stimulus-responsive processing (peptide bond cleavage) devices were developed. The processing reaction was triggered by stimulus-induced removal of a PG and the processing products were obtained in good purity. A photo-responsive processing device was successfully applied to develop a nucleocytoplasmic shuttle peptide. (F: fluorophore, NES: nuclear export signal. NLS: nuclear localization signal. PG: stimulusresponsive protective group)

This is the peer reviewed version of the following article: Shigenaga, A. , Tsuji, D. , Nishioka, N. , Tsuda, S. , Itoh, K. and Otaka, A. (2007), Synthesis of a Stimulus‐Responsive Processing Device and Its Application to a Nucleocytoplasmic Shuttle Peptide. ChemBioChem, 8: 1929-1931. doi:10.1002/cbic.200700442, which has been published in final form at https://doi.org/10.1002/cbic.200700442. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.