ID | 118916 |
著者 |
Ali, Hanif
Tokushima University
Yamanishi, Mone
Tokushima University
Sunagawa, Keigo
Tokushima University
Kumon, Mizuki
Tokushima University
Hasi, Rumana Yesmin
Tokushima University
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キーワード | Peroxisome disease
Very long-chain fatty acids
Oleic acid
Apoptosis
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資料タイプ |
学術雑誌論文
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抄録 | Very long-chain fatty acids (VLCFAs) are degraded exclusively in peroxisomes, as evidenced by the accumulation of VLCFAs in patients with certain peroxisomal disorders. Although accumulation of VLCFAs is considered to be associated with health issues, including neuronal degeneration, the mechanisms underlying VLCFAs-induced tissue degeneration remain unclear. Here, we report the toxic effect of VLCFA and protective effect of C18:1 FA in peroxisome-deficient CHO cells. We examined the cytotoxicity of saturated and monounsaturated VLCFAs with chain-length at C20-C26, and found that longer and saturated VLCFA showed potent cytotoxicity at lower accumulation levels. Furthermore, the extent of VLCFA-induced toxicity was found to be associated with a decrease in cellular C18:1 FA levels. Notably, supplementation with C18:1 FA effectively rescued the cells from VLCFA-induced apoptosis without reducing the cellular VLCFAs levels, implying that peroxisome-deficient cells can survive in the presence of accumulated VLCFA, as long as the cells keep sufficient levels of cellular C18:1 FA. These results suggest a therapeutic potential of C18:1 FA in peroxisome disease and may provide new insights into the pharmacological effect of Lorenzo's oil, a 4:1 mixture of C18:1 and C22:1 FA.
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掲載誌名 |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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ISSN | 13881981
18792618
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cat書誌ID | AA11522965
AA11300409
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出版者 | Elsevier
|
巻 | 1869
|
号 | 3
|
開始ページ | 159452
|
発行日 | 2024-01-18
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備考 | 論文本文は2025-01-18以降公開予定
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権利情報 | © 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
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EDB ID | |
出版社版DOI | |
出版社版URL | |
言語 |
eng
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著者版フラグ |
その他
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部局 |
生物資源系
薬学系
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