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ID 118916
著者
Ali, Hanif Tokushima University
Yamanishi, Mone Tokushima University
Sunagawa, Keigo Tokushima University
Kumon, Mizuki Tokushima University
Hasi, Rumana Yesmin Tokushima University
キーワード
Peroxisome disease
Very long-chain fatty acids
Oleic acid
Apoptosis
資料タイプ
学術雑誌論文
抄録
Very long-chain fatty acids (VLCFAs) are degraded exclusively in peroxisomes, as evidenced by the accumulation of VLCFAs in patients with certain peroxisomal disorders. Although accumulation of VLCFAs is considered to be associated with health issues, including neuronal degeneration, the mechanisms underlying VLCFAs-induced tissue degeneration remain unclear. Here, we report the toxic effect of VLCFA and protective effect of C18:1 FA in peroxisome-deficient CHO cells. We examined the cytotoxicity of saturated and monounsaturated VLCFAs with chain-length at C20-C26, and found that longer and saturated VLCFA showed potent cytotoxicity at lower accumulation levels. Furthermore, the extent of VLCFA-induced toxicity was found to be associated with a decrease in cellular C18:1 FA levels. Notably, supplementation with C18:1 FA effectively rescued the cells from VLCFA-induced apoptosis without reducing the cellular VLCFAs levels, implying that peroxisome-deficient cells can survive in the presence of accumulated VLCFA, as long as the cells keep sufficient levels of cellular C18:1 FA. These results suggest a therapeutic potential of C18:1 FA in peroxisome disease and may provide new insights into the pharmacological effect of Lorenzo's oil, a 4:1 mixture of C18:1 and C22:1 FA.
掲載誌名
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
ISSN
13881981
18792618
cat書誌ID
AA11522965
AA11300409
出版者
Elsevier
1869
3
開始ページ
159452
発行日
2024-01-18
備考
論文本文は2025-01-18以降公開予定
権利情報
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
言語
eng
著者版フラグ
その他
部局
生物資源系
薬学系