ID 112207
タイトル別表記
Prion protein in virus infections
著者
キーワード
prion protein
oxidative stress
influenza A virus
superoxide dismutase
copper
reactive oxygen species
資料タイプ
学術雑誌論文
抄録
The normal cellular prion protein, designated PrPC, is a membrane glycoprotein expressed most abundantly in brains, particularly by neurons, and to a lesser extent in non-neuronal tissues including lungs. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in prion diseases. We recently found that PrPC has a protective role against infection with influenza A viruses (IAVs) in mice by reducing reactive oxygen species in the lungs after infection with IAVs. The anti-oxidative activity of PrPC is probably attributable to its function to activate anti-oxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, through regulating Cu content in lungs infected with IAVs. Oxidative stress could play a pivotal role in the pathogenesis of a wide range of viral infections. Here, we introduce our and others’ studies on the role of PrPC in viral infections, and raise the attractive possibility that PrPC might be a novel target molecule for development of anti-oxidative therapeutics against not only IAV infection but also other viral infections.
掲載誌名
DNA and Cell Biology
ISSN
10445498
15577430
cat書誌ID
AA10747642
出版者
Mary Ann Liebert, Inc.
37
10
開始ページ
808
終了ページ
811
発行日
2018-10-04
備考
Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/dna.2018.4402

論文本文は2019-10-4以降公開予定
出版社版DOI
出版社版URL
言語
eng
著者版フラグ
その他
部局
先端酵素学研究所