ID | 114902 |
タイトル別表記 | BMCs and periodontal tissue healing
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著者 |
Kimura, Yasuyuki
Tokyo Medical and Dental University
Komaki, Motohiro
Tokyo Medical and Dental University
Iwasaki, Kengo
Tokyo Medical and Dental University
Izumi, Yuichi
Tokyo Medical and Dental University
Morita, Ikuo
Tokyo Medical and Dental University
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キーワード | bone marrow chimeric mice
periodontal defects
mesenchymal stem cells
recruitment
SDF-1
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資料タイプ |
学術雑誌論文
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抄録 | Bone marrow-derived cells (BMCs) are considered to be a major source of mesenchymal stem cells (MSCs) in adults and are known to be effective in periodontal tissue regeneration. However, whether endogenous BMCs are involved in periodontal tissue repair process is uncertain. We therefore created periodontal tissue defects in the buccal alveolar bone of mandibular first molars in bone marrow chimeric mice, and immunohistochemically examined the expression of stromal cell derived factor-1 (SDF-1) and the mobilization of BMCs. We found that SDF-1 expression was increased around the defects at as early as 1 week after injury and that BMCs were mobilized to the defects, while GFP+/CD45+ were rarely observed. Fluorescence-activated cell sorting (FACS) analysis demonstrated that the number of platelet-derived growth factor receptor (pdgfr) α+/Sca-1+ (PαS) cells in the bone marrow decreased after injury. Taken together, these results suggest that BMCs are mobilized to the periodontal tissue defects. Recruitment of BMCs, including a subset of MSCs could be a new target of periodontal treatment.
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掲載誌名 |
Frontiers in Cell and Developmental Biology
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ISSN | 2296634X
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出版者 | Frontiers Media S.A.
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巻 | 2
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開始ページ | 19
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発行日 | 2014-05-21
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権利情報 | © 2014 Kimura, Komaki, Iwasaki, Sata, Izumi and Morita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/3.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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言語 |
eng
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部局 |
医学系
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