ID | 118370 |
タイトル別表記 | Wnt10aおよびWnt10bのダブル変異が歯の発生に及ぼす影響
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著者 |
吉永, 薫
徳島大学大学院口腔科学研究科(口腔科学専攻)
ミツイ, シルビア ナオミ
Tokushima University
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キーワード | WNT10A
WNT10B
double mutations
oligodontia
tooth number
functional redundancy
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資料タイプ |
学位論文
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抄録 | WNT molecules are the regulators of various biological functions, including body axis formation, organ development, and cell proliferation and differentiation. WNTs have been extensively studied as causative genes for an array of diseases. WNT10A and WNT10B, which are considered to be genes of the same origin, have been identified as causative genes for tooth deficiency in humans. However, the disrupted mutant of each gene does not show a decrease in teeth number. A negative feedback loop, interacting with several ligands based on a reaction–diffusion mechanism, was proposed to be important for the spatial patterning of tooth formation, and WNT ligands have been considered to play a pivotal role in controlling tooth patterning from mutant phenotypes of LDL receptor-related proteins (LRPs) and WNT co-receptors. The Wnt10a and Wnt10b double-mutants demonstrated severe root or enamel hypoplasia. In Wnt10a-/- and Wnt10a+/-;Wnt10b-/- mice, changes in the feedback loop may collapse the modulation of fusion or split a sequence of tooth formation. However, in the double-knockout mutant, a decrease in the number of teeth was observed, including the upper incisor or third molar in both jaws. These findings suggest that there may be a functional redundancy between Wnt10a and Wnt10b and that the interaction between the two genes functions in conjunction with other ligands to control the spatial patterning and development of teeth.
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掲載誌名 |
Genes
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ISSN | 20734425
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出版者 | MDPI
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巻 | 14
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号 | 2
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開始ページ | 340
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発行日 | 2023-01-28
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Kaoru Yoshinagaの学位論文として提出され,学位審査・授与の対象となっている。 |
権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3737号
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学位記番号 | 甲口第495号
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学位授与年月日 | 2023-04-13
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学位名 |
博士(歯学)
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学位授与機関 |
徳島大学
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部局 |
病院
歯学系
先端酵素学研究所
医学系
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