ID 112817
タイトル別表記
IL-29 enhances CXCL10 production
著者
Shindo, Satoru Tokushima University
キーワード
CXCL10
IL-29
oral epithelial cells
資料タイプ
学術雑誌論文
抄録
Interleukin-29 (IL-29) is a cytokine belonging to the type III interferon family. It was recently detected in the gingival crevicular fluid of periodontitis patients. However, the role of IL-29 in the pathogenesis of periodontal disease remains unknown. The aim of this study was to examine the effects of IL-29 on C-X-C motif chemokine ligand 10 (CXCL10) production in human oral epithelial cells. We measured CXCL10 production in TR146 cells, which is a human oral epithelial cell line, using an enzyme-linked immunosorbent assay. We used Western blot analysis to detect IL-29 receptor expression and the phosphorylation levels of signal transduction molecules, including p38 mitogen-activated protein kinases (MAPK), signal transducer and activator of transcription 3 (STAT3), and nuclear factor (NF)-κB p65, in the TR146 cells. The TR146 cells expressed the IL-29 receptor. IL-29 induced CXCL10 production in the TR146 cells. IL-29 significantly enhanced CXCL10 production in tumor necrosis factor (TNF)-α-stimulated TR146 cells. The p38 MAPK, STAT3, and NF-κB pathways were found to be related to the IL-29-induced enhancement of CXCL10 production in TNF-α-stimulated TR146 cells. IL-29 promotes T helper 1 cell accumulation in periodontal lesions by inducing CXCL10 production in oral epithelial cells.
掲載誌名
Immunological Investigations : A Journal of Molecular and Cellular Immunology
ISSN
08820139
15324311
cat書誌ID
AA10519794
出版者
Taylor & Francis
46
6
開始ページ
615
終了ページ
624
発行日
2017-07-28
備考
This is an Accepted Manuscript of an article published by Taylor & Francis Group in Immunological Investigation on 28/07/2017, available online: http://www.tandfonline.com/10.1080/08820139.2017.1336176.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系