ID 111394
著者
Ebe, Koji Takao Hospital
Muneta, Tetsuo Muneta Maternity Clinic
Bando, Masahiro Tokushima University
Yonei, Yoshikazu Doshisha University
キーワード
Low carbohydrate diet
Type 2 diabetes mellitus
Ketone bodies
3-hydroxybutyric acid
β-hydroxybutyrate
Acetoacetic acid
資料タイプ
学術雑誌論文
抄録
Background: Discussion has been continued concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD). For years, authors have investigated LCD associated with lipids, renal function and Ketone Bodies (KB) for clinical application of super LCD formular meal. In this study, 3-hydroxybutyric acid (3-OHBA) and acetoacetic acid (AcAc) was measured.
Subjects and Methods: The subjects were 105 patients with type 2 diabetes mellitus (T2DM), (M/F 47/58, 62.7 years. in average) they were admitted for treatment of T2DM. The protocol consists of 3 steps. 1. Calorie Restriction (CR) diet was given on day 1 and 2 with 60% of carbohydrates. 2. Low Carbohydrate Diet (LCD) was given after day 3 with 12% of carbohydrates which is super-LCD formula meal. 3. Total ketone bodies (T-KB), 3-OHBA and AcAc were measured, and investigated the value and ratio of these markers.
Results: Median T-KB was 349, 415, 486, 415, 445 μmol/L, in day 4-6, 7-9, 10-11, 12-15, 21-30, in 5 groups.
Discussion and Conclusion: Hyperketonemia is due to continuation of LCD, which is physiological ketosis without clinically hazardous acidosis. As value of 3-OHBA increased, the ratio of 3-OHBA/T-KB increased. These results may become the fundamental data for clarifying the pathophysiological role of 3-OHBA and AcAc in hyperketonemia from carbohydrate restriction. respectively. There was significant correlation between value of 3-OHBA and ratio of 3-OHBA/T-KB (p<0.01, r=0.72). When 3-OHBA value was less or more than 1000 μmol/L, 3-OHBA ratio showed 65-89% or 90-94%, respectively.
掲載誌名
Internal Medicine : Open Access
ISSN
21658048
出版者
OMICS International
7
6
開始ページ
260
発行日
2017-11-25
権利情報
©2017 Bando H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系