ID | 114358 |
タイトル別表記 | Loss of Heterozygosity in Pheochromocytomas
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著者 |
Yokogoshi, Yutaka
The University of Tokushima
齋藤, 史郎
The University of Tokushima
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キーワード | Pheochromocytoma
Loss of heterozygosity
Oncogene
Chromosome 11
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資料タイプ |
学術雑誌論文
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抄録 | Molecular genetic analysis was performed with 20 oncogene probes and 32 polymorphic DNA probes on tumor DNA samples from seven pheochromocytomas; namely, one multiple endocrine neoplasia type 2B, and two familial and four sporadic pheochromocytomas. No amplification or rearrangement of the oncogenes was detected in any of the tumors. However, loss of heterozygosity on chromosome 1p, 11p or 11q was detected in these cases. In addition, a locus related to ETS1 was deleted in two of the sporadic tumors. These results suggest that pheochromocytomas may be genetically heterogeneous, and that inactivation of unknown genes on chromosome 1p, 11p or 11q may contribute to their development.
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掲載誌名 |
Japanese Journal of Cancer Research
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cat書誌ID | AA00690844
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出版者 | Japanese Cancer Association|John Wiley & Sons
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巻 | 81
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号 | 6-7
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開始ページ | 632
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終了ページ | 638
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発行日 | 1990-06
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
歯学系
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