ID | 114361 |
著者 |
Iwahana, Hiroyuki
The University of Tokushima
Fukuda, Ayumi
The University of Tokushima
Katsuragi, Kiyonori
Otsuka Assay Laboratories
Kinoshita, Moritoshi
Otsuka Assay Laboratories
齋藤, 史郎
The University of Tokushima
|
キーワード | ras Gene
Missense mutation
Thyroid follicular adenoma
Pheochromocytoma
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資料タイプ |
学術雑誌論文
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抄録 | To elucidate the molecular basis for endocrine tumorigenesis, ras mutations in human endocrine tumors were analyzed using polymerase chain reaction‐single strand conformation polymorphism (PCR‐SSCP) analysis. Mutations of the H‐, K‐, N‐ras genes were examined in genomic DNAs from 169 successfully amplified primary endocrine tumors out of 189 samples. Four out of 24 thyroid follicular adenomas analyzed contained mutated N‐ras codon 61, and one contained the mutated H‐ras codon 61. One of the 19 pheochromocytomas revealed mutation of the H‐ras codon 13. No mutations of the ras gene were detected in pituitary adenomas, parathyroid tumors, thyroid cancers, endocrine pancreatic tumors, and adrenocortical tumors. Based on these findings we conclude that activation of the ras gene may play a role in the tumorigenesis of a limited number of thyroid follicular adenomas and pheochromocytomas, and that mutation of the ras gene is not frequent in other human endocrine tumors.
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掲載誌名 |
Japanese Journal of Cancer Research
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cat書誌ID | AA00690844
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出版者 | Japanese Cancer Association|John Wiley & Sons
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巻 | 83
|
号 | 10
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開始ページ | 1057
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終了ページ | 1062
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発行日 | 1992-10
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
歯学系
医学系
先端酵素学研究所
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