ID | 114188 |
タイトル別表記 | Blood Pressure and Arterial Stiffness
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著者 |
Tomiyama, Hirofumi
Tokyo Medical University
Ohkuma, Toshiaki
Kyushu University
Ninomiya, Toshiharu
Kyushu University
Nakano, Hiroki
Tokyo Medical University
Matsumoto, Chisa
Tokyo Medical University
Avolio, Alberto
Macquarie University
Kohro, Takahide
Jichi Medical University
Higashi, Yukihito
Hiroshima University
Maruhashi, Tatsuya
Hiroshima University
Takase, Bonpei
National Defense Medical College
Suzuki, Toru
University of Leicester
Ishizu, Tomoko
University of Tsukuba
Ueda, Shinichiro
University of the Ryukyus
Yamazaki, Tsutomu
The University of Tokyo
Furumoto, Tomoo
Hokkaido University
Kario, Kazuomi
Jichi Medical University
Inoue, Teruo
Dokkyo Medical University
Koba, Shinji
Showa University
Takemoto, Yasuhiko
Osaka City University
Hano, Takuzo
Wakayama Medical University
Ishibashi, Yutaka
Shimane University
Node, Koichi
Saga University
Maemura, Koji
Nagasaki University
Ohya, Yusuke
University of the Ryukyus
Furukawa, Taiji
Teikyo University
Ito, Hiroshi
Okayama University
Chikamori, Taishiro
Tokyo Medical University
Yamashina, Akira
Tokyo Medical University
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キーワード | arterial stiffness
blood pressure
hypertension
organ damage
stiffness index β
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資料タイプ |
学術雑誌論文
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抄録 | Background—The difference in the predictive ability of the brachial-ankle pulse wave velocity (baPWV) and its stiffness index β-transformed value (β-baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future occurrence of cardiovascular disease was examined.
Methods and Results—In study 1, a 7-year prospective observational study in cohorts of 3274 men and 3490 men, the area under the curve in the receiver operator characteristic curve analysis was higher for baPWV than for β-baPWV for predicting the development of hypertension (0.73, 95% CI=0.70 to 0.75 versus 0.59, 95% CI=0.56 to 0.62; P<0.01) and/or the development of retinopathy (0.78, 95% CI=0.73 to 0.82 versus 0.66, 95% CI=0.60 to 0.71; P<0.01) by the end of the study period. During study 2, a 3-year observation period on 511 patients with coronary artery disease, 72 cardiovascular events were confirmed. The C statistics of both markers for predicting the development of cardiovascular events were similar. Conclusions—Stiffness index β transformation of the baPWV may attenuate the significance of the baPWV as a risk marker for development of pathophysiological abnormalities related to cardiovascular disease in male subjects. |
掲載誌名 |
Journal of the American Heart Association
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ISSN | 20479980
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出版者 | The American Heart Association
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巻 | 8
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号 | 24
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開始ページ | e013004
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発行日 | 2019-12-11
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権利情報 | © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License(https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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