ID | 114283 |
著者 |
Ueta, Shun
Tokushima University
Okamoto, Takuma
Tokushima University
|
キーワード | nitrone
flow
microreactor
nucleophilic addition
nitrogen-containing compound
|
資料タイプ |
学術雑誌論文
|
抄録 | Nucleophilic addition reactions of soft carbon nucleophiles to nitrones in a flow microreactor are reported for the first time. Under microflow conditions at 30 °C to 0 °C, a range of nitrones can be efficiently transformed into the corresponding oxyiminium ions by reacting with either acyl halides or trialkylsilyl triflates, which can subsequently undergo the addition of nucleophiles including allyltributylstannane, ketene methyl tert-butyldimethylsilyl acetal, and N-silyl ketene imines to afford the corresponding adducts in high yields, while such reactions at a similar temperature under batch conditions have resulted in lowering the yields due to undesired side reactions.
|
掲載誌名 |
Synlett
|
ISSN | 09365214
14372096
|
cat書誌ID | AA10731110
|
出版者 | Georg Thieme Verlag
|
巻 | 31
|
号 | 9
|
開始ページ | 866
|
終了ページ | 870
|
発行日 | 2020-02-18
|
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
著者版
|
部局 |
理工学系
教養教育院
|