アクセス数 : ?
ダウンロード数 : ?
ID 25668
著者
ハギ, アキフミ Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Hayashi, Hideki Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
岸, 和弘 Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Lihong, Wang Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
蛯名, 洋介 Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
fMLP
PAF
glucose transport
GLUT1
G-protein coupled receptor
資料タイプ
学術雑誌論文
抄録
The chemoattractants, fMLP and PAF, stimulate glucose uptake in phagocytes to obtain an energy source for host defense. Glucose uptake in phagocytes is mainly regulated via glucose transporter type1 (GLUT1). To examine molecular mechanisms of facilitated glucose uptake in response to fMLP or PAF, we established CHO cells stably expressing fMLP or PAF receptor with c-myc epitope tagged GLUT1 which could immunologically detect GLUT1 on the cell surface. In the CHO cells, both fMLP and PAF directly triggered GLUT1 translocation from the intracellular pool to the cell surface, and stimulated glucose uptake. Therefore, in phagocytes, we propose that fMLP and PAF also trigger GLUT1 translocation to stimulate glucose uptake as an energy source for host defense.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
47
1-2
開始ページ
19
終了ページ
28
並び順
19
発行日
2000
備考
EDB ID
フルテキストファイル
言語
eng
部局
先端酵素学研究所