アクセス数 : ?
ダウンロード数 : ?
ID 25678
著者
Tran, Yen Hai Division of Clinical Otology, The University of Tokushima School of Medicine
大崎, 勝一郎 Division of Clinical Otology, The University of Tokushima School of Medicine
イイ, クニオ First Department of Pathology, The University of Tokushima School of Medicine
Ye, Qing Department of Otolaryngology, Fujian Provincial Hospital
横関, 雅彦 Department of Orthodontics, The University of Tokushima School of Dentistry
森山, 啓司 Department of Orthodontics, The University of Tokushima School of Dentistry
キーワード
hydroxyapatite
auditory bulla bone
implant
biocompatibility
rats
資料タイプ
学術雑誌論文
抄録
To investigate the biocompatibility of a synthetic auditory ossicle to host bone, small thin Apaceram® disks composed of dense hydroxyapatite were implanted under the periosteum of the left auditory bulla in 32 rats for periods ranging from 1 day to 270days. A sham operation performed on 10 rats served as a control. Decalcified histological sections stained with hematoxylin and eosin were observed using light microscopy. The experiment showed:1) a time-dependent mature fibrous connective tissue surrounding the Apaceram® disk, 2) no evidence of inflammatory reaction caused by the implant from 90 days after implantation until the end of the experiment, 3) no evidence of osteolysis by osteoclasts caused by the implant, and 4) direct contact of bone to the implant on the bone-disk interface at 180 and 270 days after implantation. The findings suggest that Apaceram® has a high degree of implant biocompatibility, making it a satisfactory substitute biomaterial for otological reconstructive surgeries.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
47
1-2
開始ページ
56
終了ページ
60
並び順
56
発行日
2000
備考
EDB ID
フルテキストファイル
言語
eng