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ID 114919
タイトル別表記
Zerumbone Exhibits Anti-Inflammatory Functions via HSF1
著者
Igarashi, Yoko Kyoto University
大西, 康太 Kyoto University|Tokushima University
Irie, Kazuhiro Kyoto University
Murakami, Akira Kyoto University|University of Hyogo
資料タイプ
学術雑誌論文
抄録
Zerumbone is a sesquiterpene present in Zinger zerumbet. Many studies have demonstrated its marked anti-inflammatory and anti-carcinogenesis activities. Recently, we showed that zerumbone binds to numerous proteins with scant selectivity and induces the expression of heat shock proteins (HSPs) in hepatocytes. To dampen proteo-toxic stress, organisms have a stress-responsive molecular machinery, known as heat shock response. Heat shock factor 1 (HSF1) plays a key role in this protein quality control system by promoting activation of HSPs. In this study, we investigated whether zerumbone-induced HSF1 activation contributes to its anti-inflammatory functions in stimulated macrophages. Our findings showed that zerumbone increased cellular protein aggregates and promoted nuclear translocation of HSF1 for HSP expression. Interestingly, HSF1 down-regulation attenuated the suppressive effects of zerumbone on mRNA and protein expressions of pro-inflammatory genes, including inducible nitric oxide synthase and interlukin-1β. These results suggest that proteo-stress induced by zerumbone activates HSF1 for exhibiting its anti-inflammatory functions.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
11
8
開始ページ
e0161282
発行日
2016-08-18
権利情報
© 2016 Igarashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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フルテキストファイル
言語
eng
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出版社版
部局
医学系