Evaluation of Biocompatible Films Using Copolymers of N-Vinylbenzamide with Cationic Moieties by Hydrolysis of N-Vinylformamide

Biocompatible materials using poly(N-vinylamide) derivatives were developed via a recently designed synthetic route. N-Vinylbenzamide (NVB) was synthesized as typical hydrophilic N-vinylamide monomer, then copolymerized with N-vinylformamide (NVF) by free radical polymerization, which can convert to cationic polyvinylamine unit by hydrolysis. Cell toxicity on the surface of copolymer films was investigated, revealing that poly(N-vinylamide) derivatives showed biocompatibility regardless of the cationic ratio.

This is the peer reviewed version of the following article: Ryo Kawatani, Taiga Hamawaki, Tomonori Waku, Naoki Tanaka, Hiroharu Ajiro, Macromolecular Chemistry and Physics. 2023, 224, 5, 2200386., which has been published in final form at https://doi.org/10.1002/macp.202200386. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.