直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 118363
タイトル別表記
Vedolizumab for pediatric IBD
著者
Fukura, Shoko Tokushima Prefectural Central Hospital
Takei, Mikiko Tokushima Prefectural Central Hospital|Tokushima Municipal Hospital
Takeuchi, Shunsuke Tokushima Prefectural Central Hospital
田山, 貴広 Tokushima Prefectural Central Hospital
Ono, Akemi Tokushima Prefectural Central Hospital
Ichihara, Yuko Tokushima Prefectural Central Hospital
Shichijo, Koichi Tokushima Prefectural Central Hospital
Suzuki, Yasuhiro Tokushima Prefectural Central Hospital
Mori, Kazuhiro Tokushima Prefectural Central Hospital
近藤, 秀治 Tokushima Prefectural Central Hospital KAKEN研究者をさがす
キーワード
Ulcerative colitis
Inflammatory bowel disease
Vedolizumab
Infliximab
Pediatric IBD
資料タイプ
学術雑誌論文
抄録
Pediatric ulcerative colitis is likely to be more severe than adult ulcerative colitis. Failure to thrive should be considered during therapy. A 10-year-old boy was diagnosed with ulcerative colitis based on his clinical presentation and colonoscopy and biopsy results. The administration of 5-aminosalicylic acid and prednisolone resulted in remission ; however, the symptoms reappeared after the discontinuation of prednisolone. Then, infliximab was administered ; however, the patient was resistant to it and appeared to be dependent on prednisolone. Vedolizumab, a monoclonal antibody against α4β7 integrin, was administered, which resulted in rapid remission. A steady decrease in prednisolone followed, and remission was maintained even after prednisolone discontinuation. Vedolizumab may be effective in pediatric patients with moderate-to-severe refractory ulcerative colitis. Vedolizumab prevents lymphocytes from binding to MAdCAM-1, which is selectively expressed in the gastrointestinal submucosa, leading to the mitigation of the systemic side effects of immunosuppression, such as infections. In Japan, vedolizumab use is not yet approved for use in children, but its effectiveness and safety in children is expected to be investigated in the future.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
70
1-2
開始ページ
294
終了ページ
297
並び順
294
発行日
2023-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系