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ID 119339
著者
Supriya, Shakya Tsurumi University
Ushikoshi-Nakayama, Ryoko Tsurumi University
Yamazaki, Tomoe Tsurumi University
Omagari, Daisuke Tsurumi University
Inoue, Hiroko Nihon Pharmaceutical University
Matsumoto, Naoyuki Tsurumi University
Saito, Ichiro Tsurumi University
キーワード
polyphenols
non-centrifugal cane sugar
salivation
randomized controlled trial
資料タイプ
学術雑誌論文
抄録
This study examined the bioactivities and mechanisms of the non-centrifugal cane sugar polyphenols saponarin, schaftoside, and isoschaftoside in the salivary gland and their effects on salivation. In acute isolated C57BL/6N mouse submandibular gland cells, these polyphenols led to a higher increase in intracellular calcium after stimulation with the muscarinic agonist carbachol. Stimulation of these cells with polyphenols enhanced ATP production, aquaporin-5 translocation to the plasma membrane and eliminated intracellular reactive oxygen species generated by H2O2. In addition, phosphorylation of endothelial nitric oxide synthase and increased nitric oxide production in vascular endothelial cells were observed. In vivo administration of these polyphenols to C57BL/6N male mice resulted in significantly increased blood flow (saponarin, p = 0.040; isoschaftoside, p = 0.010) and salivation (saponarin, p = 0.031). A randomized controlled trial showed that intake of non-centrifugal cane sugar significantly increased saliva secretion compared with placebo (p = 0.003). These data suggest that non-centrifugal cane sugar polyphenols affect several pathways that support salivation and increase saliva secretion by enhancing vasodilation. Hence, non-centrifugal cane sugar polyphenols can be expected to maintain saliva secretion and improve reduced saliva flow.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
cat書誌ID
AA10710201
出版者
Society for Free Radical Research Japan
72
2
開始ページ
171
終了ページ
182
発行日
2023
権利情報
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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出版社版DOI
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院