直近一年間の累計
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ID 75865
著者
Ali, Abdellah Hamed Khalil Department of Respiratory Medicine, Sohag Faculty of Medicine, Sohag University|Department of Oncological Medical Services, Institute of Health Biosciences, the University of Tokushima Graduate School
滝沢, 宏光 Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
近藤, 和也 Department of Oncological Medical Services, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
中川, 靖士 Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
鳥羽, 博明 Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Khasag, Narmisheekh Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
監崎, 孝一郎 Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
先山, 正二 Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
Mohammadien, Hamdy Ali Department of Respiratory Medicine, Sohag Faculty of Medicine, Sohag University
Mokhtar, Essam Ahmed Department of Cardiothoracic Surgery, Sohag Faculty of Medicine, Sohag University
丹黒, 章 Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
lung cancer
photodynamic therapy
fluorescence bronchoscopy
資料タイプ
学術雑誌論文
抄録
Purpose : To evaluate the accuracy of fluorescence bronchoscopy by precise histological analysis of the photodynamic therapy (PDT) treated lesions. Methods : A retrospective study was conducted on thirteen patients (16 lesions) with centrally located early lung cancer (CLELC) had been undergone photodynamic therapy and had been followed up by fluorescence bronchoscopy. Fluorescence bronchoscopy was performed between 1 and 60 months after photodynamic therapy. Results : Of the 16 early carcinomas treated, 14 (87.5%) had a CR, 2 (12.5%) had a NR after initial PDT. Among the 14 carcinomas achieving a CR, 4 (29%) recurred locally from 6 to 12 months after initial PDT. A total of 62 surveillance auto fluorescence bronchoscopies (average ; 4.5/patient) and 47 biopsies (average ; 4/patient) were performed after PDT. The addition of the SAFE-3000 examination to conventional bronchoscopy increased the sensitivity of screening from 69% to 100%, which yielded a relative sensitivity of 145% with a negative predictive value of 100%. Out of 14 CR lesions, 9 lesions finally reverted to normal fluorescence. CR cases that did not show normal fluorescence were relapsed cases or a patient with complete response whose treated lesion showed fibrosis in the sub mucosa. Histopathological finding of the complete response sites which demonstrated temporal fluorescent defect consisted of inflammatory lesions, goblet cell hyperplasia, basal cell hyperplasia, squamous metaplasia or dysplasia. Conclusion : our results confirm that SAFE-3000 allows accurate assessment of the quality and efficacy of PDT.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
58
1-2
開始ページ
46
終了ページ
55
並び順
46
発行日
2011-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng
部局
医学系