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大脳皮質体性感覚野の口腔領域における局所回路オシレーションに対するGABAB受容体の作用 : NMDA受容体に焦点を当てて
著者
金山, 宏幸 徳島大学大学院口腔科学研究科(口腔科学専攻)
Tominaga, Takashi Tokushima Bunri University
Tominaga, Yoko Tokushima Bunri University
Kato, Nobuo Kanazawa Medical University
キーワード
Caffeine
GABAB receptor
NMDA receptor
Network oscillation
Oral somatosensory cortex
Voltage-sensitive dye
資料タイプ
学位論文
抄録
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosensory cortex (OSC), focusing on NMDA receptors. Neural oscillation at the frequency of 8–10 Hz was elicited in rat brain slices after caffeine application. Oscillations comprised a non-NMDA receptor-dependent initial phase and a later NMDA receptor-dependent oscillatory phase, with the oscillator located in the upper layer of the OSC. Baclofen was applied to investigate the actions of GABAB receptors. The later NMDA receptor-dependent oscillatory phase completely disappeared, but the initial phase did not. These results suggest that GABAB receptors mainly act on NMDA receptor, in which metabotropic actions of GABAB receptors may contribute to the attenuation of NMDA receptor activities. A regulatory system for network oscillation involving GABAB receptors may be present in the OSC.
掲載誌名
The Journal of Physiological Sciences
ISSN
18806546
18806562
cat書誌ID
AA12129145
出版者
BioMed Central/Springer Nature
74
開始ページ
16
発行日
2024-03-12
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroyuki Kanayamaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3789号
学位記番号
甲口第503号
学位授与年月日
2024-03-14
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系