ドイ, ナオヤ Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧
フジワラ, サチ Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
足立, 昭夫 Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
We have recently constructed a series of novel human immunodeficiency viruses (HIV-1s) that are tropic for a macaque cell line (mt ; macaque cell-tropic) to generate and establish a primate experimental system for HIV-1/AIDS study. In order to determine biological properties of these viruses effectively, several other macaque cell lines with distinct characteristics that can be routinely and easily used, instead of primary cells, for infection experiments are required. In this study, we have examined four macaque cell lines for their surface expression of virus receptor molecules and for their genotype of a major anti-viral capsid gene. Furthermore, we monitored the susceptibility of the cell lines to a standard simian immunodeficiency virus (SIV) clone and three representative basic mt HIV-1 clones. Results obtained here have clearly indicated that these cell lines are exquisitely useful to characterize various SIVs and more importantly, mt HIV-1s.
The journal of medical investigation : JMI
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
LID201112142004.pdf 1.11 MB