メタボリックシンドロームおよび代謝的に不健康な肥満とがん死亡率との関連 : 日本多施設共同コーホート（J-MICC）研究
Metabolic syndrome and metabolically unhealthy obesity with cancer mortality
グエン, ティエン バン 徳島大学大学院医学研究科（医学専攻）
Nagayoshi, Mako Nagoya University
Okada, Rieko Nagoya University
Hishida, Asahi Nagoya University
Tamura, Takashi Nagoya University
Hara, Megumi Saga University
Tanaka, Keitaro Saga University
Nishimoto, Daisaku Kagoshima University
Shibuya, Keiichi Kagoshima University
Koyama, Teruhide Kyoto Prefectural University of Medicine
Watanabe, Isao Kyoto Prefectural University of Medicine
Suzuki, Sadao Nagoya City University
Nishiyama, Takeshi Nagoya City University
Kuriki, Kiyonori University of Shizuoka
Nakamura, Yasuyuki Shiga University of Medical Science
Saito, Yoshino Aino University
Ikezaki, Hiroaki Kyushu University
Otonari, Jun Kyushu University
Koyanagi, Yuriko N. Aichi Cancer Center Research Institute
Matsuo, Keitaro Aichi Cancer Center Research Institute
Mikami, Haruo Chiba Cancer Center Research Institute
Kusakabe, Miho Chiba Cancer Center Research Institute
Takeuchi, Kenji Nagoya University
Wakai, Kenji Nagoya University
Metabolically unhealthy obesity
The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.
We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined.
During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05).
MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.
本論文は，著者Tien Van Nguyenの学位論文として提出され，学位審査・授与の対象となっている。
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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