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ID 114664
タイトル別表記
生後早期の心理的ストレスが雌雄ラットの性成熟、性行動に与える影響
著者
矢野, 清人 徳島大学大学院医科学教育部(医学専攻)
松崎, 利也 Tokushima University|Yoshinogawa Medical Center KAKEN研究者をさがす
Mayila, Yiliyasi Tokushima University
Yanagihara, Rie Tokushima University
Tungalagsuvd, Altankhuu Tokushima University|National Center for Maternal and Child Health
Munkhzaya, Munkhsaihan Tokushima University|The First Maternity Hospital of Mongolia
Tokui, Takako Tokushima University
Hayashi, Aki Tokushima University
Masaki, Rie Yoshinogawa Medical Center
Aoki, Hidenori Tokushima University
Tamura, Kou Tokushima University
キーワード
maternal separation
sexual maturation
sexual behavior
early life stress
psychological stress
neonatal period
資料タイプ
学位論文
抄録
Purpose: We studied the influence of psychological stress during the early neonatal period on sexual maturation and sexual behavior in rats.
Methods: Neonatal male and female rats were divided into control (C) and maternal separation (MS) groups (n = 20‐24 per group). The pups in the MS groups were placed in isolation cages for 240 minutes/d from postnatal days 2‐11. Vaginal opening (VO) in females and preputial separation (PS) in males (indicators of sexual maturation) were monitored, as was the estrous cycle in females. Thereafter, sexual behavior was monitored twice at 13 and 15 weeks of age.
Results: As for sexual maturation, the onset of PS occurred significantly earlier in the MS group than in the C group, whereas the onset of VO did not differ between the groups. The length of the estrous cycle did not differ between the groups. The frequencies of sexual behaviors did not differ between the groups in either sex.
Conclusions: In conclusion, early‐life psychological stress induced by MS advanced sexual maturation in male rats, whereas it did not affect sexual maturation in female rats. On the other hand, early‐life psychological stress might not affect sexual behavior in adulthood in either sex.
掲載誌名
Reproductive Medicine and Biology
ISSN
14470578
cat書誌ID
AA11706516
出版者
Wiley|Japan Society for Reproductive Medicine
19
2
開始ページ
135
終了ページ
141
発行日
2019-12-26
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Kiyohito Yanoの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
This is an open access article under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
© 2019 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3364号
学位記番号
甲医第1447号
学位授与年月日
2020-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系