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ID 118063
著者
Ohmura, Takuya Biozentrum University of Basel
Hanibuchi, Yuto Tokushima University
宮澤, 龍一郎 Tokushima University
キーワード
AIRE
bioinformatics
single-cell RNA-seq
The Cancer Genome Atlas
thymic carcinoma
thymic epithelial tumor
資料タイプ
学術雑誌論文
抄録
Despite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by focusing on AIRE, an mTEC-specific transcriptional regulator that is required for immunological self-tolerance. We found that a large proportion of TCs expressed AIRE with typical nuclear dot morphology by immunohistochemistry. AIRE expression in TCs was supported by the RNA-seq data in the TCGA-THYM database. Furthermore, our bioinformatics approach to the recent single-cell RNA-seq data on human thymi has revealed that TCs hold molecular characteristics of multiple mTEC subpopulations. In contrast, TCs lacked the gene signatures for cTECs. We propose that TCs are tumors derived from mTECs.
掲載誌名
Cancer Medicine
ISSN
20457634
出版者
John Wiley & Sons
12
8
開始ページ
9843
終了ページ
9848
発行日
2023-03-13
権利情報
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
先端酵素学研究所
病院