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ID 117591
タイトル別表記
メタボリックシンドロームおよび代謝的に不健康な肥満とがん死亡率との関連 : 日本多施設共同コーホート(J-MICC)研究
Metabolic syndrome and metabolically unhealthy obesity with cancer mortality
著者
グエン, ティエン バン 徳島大学大学院医学研究科(医学専攻)
Nagayoshi, Mako Nagoya University
Okada, Rieko Nagoya University
Hishida, Asahi Nagoya University
Tamura, Takashi Nagoya University
Hara, Megumi Saga University
Tanaka, Keitaro Saga University
Nishimoto, Daisaku Kagoshima University
Shibuya, Keiichi Kagoshima University
Koyama, Teruhide Kyoto Prefectural University of Medicine
Watanabe, Isao Kyoto Prefectural University of Medicine
Suzuki, Sadao Nagoya City University
Nishiyama, Takeshi Nagoya City University
Kuriki, Kiyonori University of Shizuoka
Nakamura, Yasuyuki Shiga University of Medical Science
Saito, Yoshino Aino University
Ikezaki, Hiroaki Kyushu University
Otonari, Jun Kyushu University
Koyanagi, Yuriko N. Aichi Cancer Center Research Institute
Matsuo, Keitaro Aichi Cancer Center Research Institute
Mikami, Haruo Chiba Cancer Center Research Institute
Kusakabe, Miho Chiba Cancer Center Research Institute
Takeuchi, Kenji Nagoya University
Wakai, Kenji Nagoya University
キーワード
Cancer mortality
Cohort study
Metabolic syndrome
Metabolically unhealthy obesity
Japanese
資料タイプ
学位論文
抄録
Purpose
The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.
Methods
We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined.
Results
During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05).
Conclusion
MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
17
7
開始ページ
e0269550
発行日
2022-07-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Tien Van Nguyenの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3696号
学位記番号
甲医第1565号
学位授与年月日
2023-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系